Cajun Chicken Alfredo Fettuccine

Featured in: Cozy Weeknight Meals

This dish highlights juicy chicken breasts seasoned with bold Cajun spices, paired with perfectly cooked fettuccine. A luscious Velveeta cheese sauce enriched with garlic, cream, and Parmesan envelops the pasta, balancing heat and creaminess. Garnished with fresh parsley and optional extra Parmesan, it offers a comforting Southern-inspired meal ready in just 40 minutes, easily adjusted for spice and variations.

Updated on Sun, 23 Nov 2025 16:00:00 GMT
A close-up of creamy Cajun Chicken Alfredo Fettuccine, topped with fresh parsley for a vibrant dish. Save
A close-up of creamy Cajun Chicken Alfredo Fettuccine, topped with fresh parsley for a vibrant dish. | blipbite.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish quickly became a family favorite after I served it for a weekend dinner—the cheesy sauce is irresistible!

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts, 1 ½ tablespoons Cajun seasoning, 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter, 2 cloves garlic, minced, 1 cup (240 ml) heavy cream, 8 oz (225 g) Velveeta cheese cubed, ½ cup (50 g) grated Parmesan cheese, ½ teaspoon black pepper, ¼ teaspoon cayenne pepper (optional, for extra heat), salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped, extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside, reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side, or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken, let rest 5 minutes, then slice thinly.
Step 4:
In the same skillet, reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring often until melted and smooth.
Step 6:
Add Parmesan cheese, black pepper, and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick, add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
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This meal always brings my family together for a cozy dinner full of laughter and compliments.

Notes

Add sautéed bell peppers or mushrooms for extra flavor and color

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta, Parmesan, cream, butter), contains wheat (fettuccine), contains chicken. Check ingredient labels for hidden allergens.

Savory and spicy Cajun Chicken Alfredo Fettuccine: tender chicken atop rich, cheesy pasta ready to eat. Save
Savory and spicy Cajun Chicken Alfredo Fettuccine: tender chicken atop rich, cheesy pasta ready to eat. | blipbite.com

Serve immediately for best texture and flavor.

Kitchen Guide

What is the best way to cook the chicken for this dish?

Sear boneless, skinless chicken breasts in olive oil over medium-high heat until golden and cooked through, about 5–6 minutes per side, then rest before slicing thinly.

Can I adjust the heat level of the sauce?

Yes, add or omit cayenne pepper to suit your preferred spice level, and adjust Cajun seasoning accordingly.

How do I prevent the cheese sauce from becoming too thick?

If the sauce thickens too much, stir in reserved pasta water a little at a time until desired consistency is reached.

Is it possible to use different pasta instead of fettuccine?

Absolutely, other flat or ribbon-shaped pastas like linguine or tagliatelle can be substituted while keeping the sauce coating well.

What garnishes complement this dish?

Fresh chopped parsley adds brightness, and extra grated Parmesan enhances the creamy flavors.

Cajun Chicken Alfredo Fettuccine

Spicy Cajun chicken meets creamy Velveeta sauce tossed with fettuccine for a flavorful main dish.

Prep duration
15 min
Heat time
25 min
Complete duration
40 min
Created by Megan Lewis


Complexity Easy

Heritage American (Cajun-inspired)

Output 4 Portions

Nutrition Guidelines None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 1/2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 1/2 cup grated Parmesan cheese
06 1/2 teaspoon black pepper
07 1/4 teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Method

Phase 01

Cook Fettuccine: Bring a large pot of salted water to a boil. Add the fettuccine and cook according to package instructions until al dente. Drain, reserving 1/2 cup pasta water, and set pasta aside.

Phase 02

Prepare Chicken: Pat chicken breasts dry and rub both sides evenly with Cajun seasoning.

Phase 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden brown and fully cooked (internal temperature 165°F). Remove from skillet, let rest 5 minutes, then slice thinly.

Phase 04

Sauté Garlic: Reduce heat to medium. Add butter and minced garlic to the same skillet and sauté for 1 minute until fragrant.

Phase 05

Create Cheese Sauce: Pour in heavy cream and bring to a gentle simmer. Add Velveeta cheese cubes and stir frequently until melted and smooth.

Phase 06

Season Sauce: Incorporate grated Parmesan, black pepper, and cayenne pepper if desired. Stir until sauce reaches a creamy consistency. If too thick, gradually add reserved pasta water to adjust texture.

Phase 07

Combine Pasta and Sauce: Toss cooked fettuccine in the cheese sauce thoroughly to coat.

Phase 08

Plate and Garnish: Divide pasta among plates, top with sliced Cajun chicken, and garnish with chopped parsley and additional Parmesan cheese if desired.

Tools needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Details

Review ingredients carefully for potential allergens and seek professional medical guidance if uncertain.
  • Contains dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine)
  • Contains poultry (chicken)

Nutrient breakdown (per portion)

Values shown are estimates and shouldn't replace professional medical consultation.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g